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The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer |
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| Authors: | Atena Soleimani Farzad Rahmani Nikoo Saeedi Rana Ghaffarian Majid Khazaei Gordon A. Ferns Amir Avan Seyed Mahdi Hassanian |
| Affiliation: | 1. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Atena Soleimani and Farzad Rahmani made equal contribution to this study.;2. Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran;3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex, UK;5. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Dysregulation of RAS/MAPK signaling axis is frequently found in CRC patients. The RAS/MAPK axis regulates cancer cell proliferation, apoptosis, inflammation, migration, and metastasis. Oncogenic or tumor-suppressor microRNAs (miRNAs) for RAS/MAPK signaling play a key role in the pathogenesis of CRC and are considered as novel potential biomarkers for diagnosis and prognosis of human malignancies. This review summarizes the current knowledge of mechanisms of action of RAS/MAPK miRNAs in the development and progression of CRC for a better understanding and hence a better management of this disease. |
| Keywords: | colorectal cancer microRNA RAS/MAPK signaling |