Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation |
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Authors: | Chiharu Fujihara Yu Kanai Risa Masumoto Jirouta Kitagaki Masahiro Matsumoto Satoru Yamada Tetsuhiro Kajikawa Shinya Murakami |
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Affiliation: | 1. Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan;2. Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan C.F. and Y.K. have contributed equally to the work.;3. Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Miyagi, Japan |
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Abstract: | Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti-inflammatory effect of FGF-2 during periodontal regeneration and healing. We found that FGF-2 on mouse periodontal ligament cells (MPDL22) markedly downregulated CD40 expression, a key player of inflammation. In addition, FGF-2 inhibited CD40 signaling by the non-canonical nuclear factor-kappa B2 (NFκB2) pathway, resulting in decreased production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), which have the potential to recruit immune cells to inflamed sites. Furthermore, in vivo treatment of FGF-2 enhanced healing of skin wounds by counteracting the CD40-mediated inflammation. These results reveal that FGF-2 has an important function as a negative regulator of inflammation during periodontal regeneration and healing. |
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Keywords: | anti-inflammation CD40 fibroblast growth factor-2 (FGF-2) periodontal ligament (PDL) cells wound healing |
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