The crosstalk between trace elements with DNA damage response,repair, and oxidative stress in cancer |
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| Authors: | Sadra Samavarchi Tehrani Hamideh Mahmoodzadeh Hosseini Tooba Yousefi Maryam Abolghasemi Durdi Qujeq Mahmood Maniati Jafar Amani |
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| Institution: | 1. Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. Student Research Committee, Babol University of Medical Sciences, Babol, Iran;3. Department of Clinical Biochemistry, Babol University of Medical Sciences, Babol, Iran;4. English Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
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| Abstract: | DNA damage response (DDR) is a regulatory system responsible for maintaining genome integrity and stability, which can sense and transduce DNA damage signals. The severity of damage appears to determine DDRs, which can include damage repair, cell-cycle arrest, and apoptosis. Furthermore, defective components in DNA damage and repair machinery are an underlying cause for the development and progression of various types of cancers. Increasing evidence indicates that there is an association between trace elements and DDR/repair mechanisms. In fact, trace elements seem to affect mediators of DDR. Besides, it has been revealed that oxidative stress (OS) and trace elements are associated with cancer development. In this review, we discuss the role of some critical trace elements in the risk of cancer. In addition, we provide a brief introduction on DDR and OS in cancer. Finally, we will further review the interactions between some important trace elements including selenium, zinc, chromium, cadmium, and arsenic, and DDR, and OS in cancer. |
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| Keywords: | cancer DNA damage response trace elements oxidative stress |
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