Salidroside attenuates interleukin-1β-induced inflammation in human osteoarthritis chondrocytes |
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| Authors: | Yuan Zhang Qing Zhao |
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| Institution: | 1. Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, Henan, China;2. Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, Henan, China
Yuan Zhang and Qing Zhao contributed equally to this work. |
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| Abstract: | Salidroside, a bioactive constituent isolated from Rhodiola rosea, has been reported to have anti-inflammatory effects. However, the effects of salidroside on interleukin (IL)-1β-stimulated osteoarthritis (OA) chondrocytes remain to be elucidated. Thus, this study aimed to evaluate the anti-inflammatory effects of salidroside on IL-1β-stimulated human OA chondrocytes and explore its underlying mechanisms. Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1β-stimulated chondrocytes ( P < .05). In addition, salidroside also suppressed IL-1β-induced matrix metalloproteinases production in human OA chondrocytes ( P < .05). Furthermore, pretreatment with salidroside prevented IL-1β-induced NF-κB activation in OA chondrocytes ( P < .05). In conclusion, the current study demonstrated that salidroside inhibited the IL-1β-induced inflammatory response in OA chondrocytes via inhibition of NF-κB activation. |
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| Keywords: | inflammatory response NF-κB pathway osteoarthritis (OA) salidroside |
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