Tumor-derived exosomes: Implication in angiogenesis and antiangiogenesis cancer therapy |
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| Authors: | Cynthia Aslan Sepideh Maralbashi Farhad Salari Houman Kahroba Faraz Sigaroodi Tohid Kazemi Pedram Kharaziha |
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| Affiliation: | 1. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;6. Department of Clinical Genetics, Linköping University Hospital, Linköping, Sweden |
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| Abstract: | Tumor cells utilize different strategies to communicate with neighboring tissues for facilitating tumor progression and invasion, one of these strategies has been shown to be the release of exosomes. Exosomes are small nanovesicles secreted by all kind of cells in the body, especially cancer cells, and mediate cell to cell communications. Exosomes play an important role in cancer invasiveness by harboring various cargoes that could accelerate angiogenesis. Here first, we will present an overview of exosomes, their biology, and their function in the body. Then, we will focus on exosomes derived from tumor cells as tumor angiogenesis mediators with a particular emphasis on the underlying mechanisms in various cancer origins. Also, exosomes derived from stem cells and tumor-associated macrophages will be discussed in this regard. Finally, we will discuss the novel therapeutic strategies of exosomes as drug delivery vehicles against angiogenesis. |
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| Keywords: | angiogenesis cancer therapy exosomes extracellular vesicles tumor |
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