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Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish
Authors:Gang Wang  Qi Xiao  Yao Wu  Ying-jie Wei  Yue Jing  Xiang-rong Cao  Zhu-nan Gong
Affiliation:1. Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, People's Republic of China;2. Key Laboratory of Oral Drug Delivery System of Chinese Meteria Media of State Administration of Tradition Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing, People's Republic of China;3. Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China;4. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People's Republic of China
Abstract:
Keywords:absorption  bioactivity  celastrol derivative  toxicity  zebrafish
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