Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials |
| |
Authors: | Mohammad Mohajeri Behzad Behnam Amirhossein Sahebkar |
| |
Affiliation: | 1. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Mohajeri and Behzad Behnam equally contributed as the first author.;2. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran Mohammad Mohajeri and Behzad Behnam equally contributed as the first author.;3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
| |
Abstract: | One of the major components in the development of nanomedicines is the choice of the right biomaterial, which notably determines the subsequent biological responses. The popularity of carbon nanomaterials (CNMs) has been on the rise due to their numerous applications in the fields of drug delivery, bioimaging, tissue engineering, and biosensing. Owing to their considerably high surface area, multifunctional surface chemistry, and excellent optical activity, novel functionalized CNMs possess efficient drug-loading capacity, biocompatibility, and lack of immunogenicity. Over the past few decades, several advances have been made on the functionalization of CNMs to minimize their health concerns and enhance their biosafety. Recent evidence has also implied that CNMs can be functionalized with bioactive peptides, proteins, nucleic acids, and drugs to achieve composites with remarkably low toxicity and high pharmaceutical efficiency. This review focuses on the three main classes of CNMs, including fullerenes, graphenes, and carbon nanotubes, and their recent biomedical applications. |
| |
Keywords: | biomedicine carbon nanotubes drug delivery fullerene gene delivery graphene |
|
|