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The role of pretreatment prognostic nutritional index in esophageal cancer: A meta-analysis |
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| Authors: | Yibo Xue Xiang Zhou Lei Xue Ruhua Zhou Jinhua Luo |
| Affiliation: | 1. Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Xue and Zhou have contributed equally to this work.;2. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Xue and Zhou have contributed equally to this work.;3. College of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China;4. Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China |
| Abstract: | Clinicopathological characteristics and prognosis of esophageal cancer (EC) patients with decreased prognostic nutritional index (PNI) have not been well investigated. So, we conducted this meta-analysis. We performed comprehensive research in PubMed, Embase, and Cochrane databases. The effect size was hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS) and cancer-specific survival (CSS). The pooled odds ratio (OR) with 95% CI were used to assess the association between PNI and clinicopathological features. A total of 3,425 EC patients were included in the present meta-analysis. Male patients, advanced age, higher tumor stage, and lymph node metastases were associated with reduced PNI level (OR = 1.40, 95% CI: 1.10-1.79; OR = 1.35, 95% CI: 1.10-1.66; OR = 2.37, 95% CI: 1.91-2.94; OR = 1.63, 95% CI: 1.04-2.56). And, the EC patients with decreased PNI held a worse OS and CSS compared with those who carried a higher PNI (HR = 1.29, 95% CI: 1.10-1.50; HR = 2.53, 95% CI: 1.15-5.57). This meta-analysis demonstrated PNI level was associated with tumor stage and lymph nodes metastases and was an independent prognostic factor in EC. |
| Keywords: | esophageal cancer meta-analysis pretreatment prognosis prognostic nutritional index |