Adipose-derived stem cells for wound healing |
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| Authors: | Alireza Hassanshahi Mohammadhossein Hassanshahi Samira Khabbazi Zahra Hosseini-Khah Yaser Peymanfar Saman Ghalamkari Yu-Wen Su Cory J Xian |
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| Institution: | 1. Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran;2. School of Pharmacy and Medical Sciences, University of South Australia Cancer Research Institute, University of South Australia, Adelaide, South Australia, Australia;3. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;4. Department of Biology, Islamic Azad University, Arsanjan, Iran |
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| Abstract: | Wound healing is a complex but a fine-tuned biological process in which human skin has the ability to regenerate itself following damage. However, in particular conditions such as deep burn or diabetes the process of wound healing is compromised. Despite investigations on the potency of a wide variety of stem cells for wound healing, adipose-derived stem cells (ASCs) seem to possess the least limitations for clinical applications, and literature showed that ASCs can improve the process of wound healing very likely by promoting angiogenesis and/or vascularisation, modulating immune response, and inducing epithelialization in the wound. In the present review, advantages and disadvantages of various stem cells which can be used for promoting wound healing are discussed. In addition, potential mechanisms of action by which ASCs may accelerate wound healing are summarised. Finally, clinical studies applying ASCs for wound healing and the associated limitations are reviewed. |
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| Keywords: | adipose-derived stem cells angiogenesis mesenchymal stem cells stem cells stromal vascular fraction wound healing |
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