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Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption |
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| Authors: | Qiang Guo Zhen Cao Bo Wu Fangxiao Chen Jennifer Tickner Ziyi Wang Heng Qiu Chao Wang Kai Chen Renxiang Tan Qile Gao Jiake Xu |
| Institution: | 1. Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China
School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia Qiang Guo and Zhen Cao contributed equally to this work.;2. School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia Department of Biomedical Materials Science, Third Military Medical University, Chongqing, China Qiang Guo and Zhen Cao contributed equally to this work.;3. Department of Orthopedics, The Second Affiliate Hospital, School of Medicine, Zhejiang University, Hangzhou, China;4. Department of Surgery, Chinese People’s Liberation Army 66325 Hospital, Beijing, China;5. School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia;6. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, China State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, China;7. Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, China |
| Abstract: | |
| Keywords: | bone resorption calcium kavain MAPK osteoclast |