RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants |
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Authors: | Jian Wang Wei Yuan Chuang Yue Feng Dai Shenglin Gao Yuanyuan Mi Yu Bai Lifeng Zhang Li Zuo Xingyu Wu Wei Zhang |
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Affiliation: | 1. Department of Urology, Third Affiliated Hospital of Nantong University (Affiliated Hospital of Jiangnan University), Wuxi, China;2. Department of Cardiology, Taizhou People's Hospital, Taizhou, Jiangsu, China;3. Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, China;4. Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu, China |
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Abstract: | Association between ribonuclease L (RNASEL) gene 1623A>C polymorphism and prostate cancer (PCa) susceptibility has been assessed in large quantities of studies but with controversial conclusions. We undertook a pooled analysis containing 7397 PCa cases and 6088 control subjects to assess the correlation between RNASEL 1623A>C polymorphism and PCa risk. Moreover, we used enzyme-linked immunosorbent assay to test the serum RNASEL expression among patients enrolled in our centers and in-silico tools were also utilized. The overall results of our analysis indicated a positive relationship between 1623A>C variant and PCa risk (allelic contrast, odds ratio [OR] = 1.07; 95% confidence interval [CI] = 1.02-1.12; Pheterogeneity = 0.575; CC vs AA, OR = 1.14; 95% CI = 1.03-1.26; Pheterogeneity = 0.217; CC + CA vs AA, OR = 1.10; 95% CI = 1.01-1.19; Pheterogeneity = 0.303; and CC vs CA + AA, OR = 1.08; 95% CI = 1.00-1.17; Pheterogeneity = 0.298). In ethnicity subgroup analysis, similar results were especially indicated in African descendants. In addition, serum RNASEL levels in PCa cases with CC + CA genotypes were higher than those with AA genotypes. Our present study showed evidence that RNASEL 1623A>C polymorphism is related to PCa risk, especially in African descendants. |
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Keywords: | enzyme-linked immunosorbent assay genetic variation polymorphism prostate cancer ribonuclease L |
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