Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride-induced hepatotoxicity in rats |
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| Authors: | Hasan Yousefi-Manesh Samira Shirooie Alireza Partoazar Vahid Nikoui Mohammad Reza Abdollahzadeh Estakhri Azam Bakhtiarian |
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| Institution: | 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;2. Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran;5. Diagnosis Lab, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl4-induced hepatotoxicity in a rat model. Male Wistar rats were treated with PS (10 mg/kg, oral) or phosphatidylcholine liposomes (PC) (10 mg/kg, oral) for 3 days before CCl4 (2 ml/kg; ip once on the third day) injection. The serum level of ALT, AST, and ALP were measured. Also, antioxidant assays were performed. Administration of PS with CCl4 significantly inhibited alterations in the serum levels of AST, ALP (**P < 0.01), and ALT (***P < 0.001) compared with control group. Furthermore, measurement of malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) levels indicated that PS significantly reduced reactive oxygen species. The results of the present study showed the hepatoprotective effects of PS against CCl4-induced hepatotoxicity in rats. |
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| Keywords: | antioxidant CCl4 hepatoprotective liposome phosphatidylserine |
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