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Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes |
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| Authors: | Gaohua Li Hua Liu Chunlian Ma Yanfang Chen Jinju Wang Yi Yang |
| Institution: | 1. School of Physical Education, Henan Agricultural University, Zhengzhou, China
Hubei Key Laboratory of Exercise Training and Monitoring,College of Health Science, Wuhan Sports University, Wuhan, China Gaohua Li and Hua Liu contributed equally to this work.;2. Hubei Key Laboratory of Exercise Training and Monitoring,College of Health Science, Wuhan Sports University, Wuhan, China;3. Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio |
| Abstract: | Exosomes contain regulatory signals such as lipids, proteins, and nucleic acids which can be transferred to adjacent or remote cells to mediate cell-to-cell communication. Exercise is a positive lifestyle for metabolic health and a nonpharmacological treatment of insulin resistance and metabolic diseases. Moreover, exercise is a stressor that induces cellular responses including gene expression and exosome release in various types of cells. Exosomes can carry the characters of parent cells by their modified cargoes, representing novel mechanisms for the effects of exercise. Here, we present a review of exosomes as the perspective players in mediating exercise's beneficial impacts on type 2 diabetes (T2D). |
| Keywords: | exercise exosomes lncRNAs miRNA type 2 diabetes |