|
|||||
|
|
LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma |
|
| Authors: | Peng-Fei Zhang Fei Wang Jing Wu Yin Wu Wei Huang Dong Liu Xiao-Yong Huang Xue-Mei Zhang Ai-Wu Ke |
| Institution: | 1. Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai, China
Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China Zhang, Wang, and Wu have contributed equally to this work.;2. Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China Zhang, Wang, and Wu have contributed equally to this work.;3. Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;4. Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai, China |
| Abstract: | Dysregulation of long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and tumor progression, including hepatocellular carcinoma (HCC). Small nucleolar RNA host gene 3 (SNHG3) has been considered as an lncRNA to be associated with a poor prognosis in patients with HCC. Here, we reported that SNHG3 expression was significantly higher in the highly metastatic HCC (HCCLM3) cells compared with the lowly metastatic HCC cells (Hep3B and PLC/PRF/5). Furthermore, forced expression of SNHG3 promoted cell invasion, epithelial-mesenchymal transition (EMT), and sorafenib resistance in HCC. Moreover, SNHG3 overexpression induced HCC cells EMT via miR-128/CD151 cascade activation. Clinically, our data revealed that increased SNHG3 expression is correlated with poor HCC survival outcomes and sorafenib response. These data suggest that SNHG3 may be a novel therapeutic target and a biomarker for predicting response to sorafenib treatment of HCC. |
| Keywords: | epithelial-mesenchymal transition (EMT) hepatocellular carcinoma (HCC) small nucleolar RNA host gene 3 (SNHG3) sorafenib resistance |