|
|||||
|
|
HHEX gene polymorphisms and type 2 diabetes mellitus: A case-control report from Iran |
|
| Authors: | Hamidreza Galavi Fatemeh Mollashahee-Kohkan Ramin Saravani Saman Sargazi Nafiseh Noorzehi Hojat Shahraki |
| Institution: | 1. Cellular and Molecular Research Center, Ali ibn Abi Talib Hospital, Zahedan University of Medical Sciences, Zahedan, Iran;2. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran;3. Cellular and Molecular Research Center, Ali ibn Abi Talib Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
Department of Clinical Biochemistry and Molecular Biology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;4. Department of Biology, Zabol University, Zabol, Iran;5. Department of Laboratory Sciences, School of Allied Medicine, Zahedan University of Medical Sciences, Zahedan, Iran |
| Abstract: | Genome-wide association studies indicated that hematopoietically-expressed homeobox (HHEX) gene is a remarkable candidate for type 2 diabetes (T2D) mellitus susceptibility in spite of the fact that the results are ambiguous in some cases. So, this study aimed to evaluate the possible correlation between HHEX gene polymorphisms and T2D development in a sample of the Iranian population. The rs1111875G/A, rs7923837A/G, and rs5015480C/T HHEX gene polymorphisms were genotyped in 250 cases and 250 matched (age and sex) healthy controls using tetra-amplification-refractory mutation system-polymerase chain reaction method. The finding revealed the all measured inheritance models of rs1111875G/A and of rs5015480C/T variants dramatically increase the risk of T2D while another polymorphism (rs7923837A/G) was not associated with risk/protective role in T2D. The results indicated that rs1111875G/A and rs5015480C/T may contribute to the enhancement of T2D risk in a sample of the southeast Iranian population. |
| Keywords: | and haplotype gene polymorphism hematopoietically-expressed homobox (HHEX) type 2 diabetes |