miR-145 is a potential biomarker for predicting clinical outcome in glioblastomas |
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| Authors: | Lei Shi Bin Wang Xiaoyan Gu Shuguang Zhang Xiaoliang Li Haifeng Zhu |
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| Institution: | 1. Department of Neurosurgery, First People’s Hospital of Kunshan, affiliated with Jiangsu University, Suzhou, China;2. Department of Rehabilitation, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China;3. Department of Neurosurgery, Funing People’s Hospital, Funing, China |
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| Abstract: | miR-145 has been found to be significantly downregulated in gliomas, and overexpression of miR-145 increases glioma cell apoptosis and enhances chemosensitivity or herpes simplex virus thymidine kinase gene therapy. However, the correlation between miR-145 and the clinical prognosis of glioblastomas has never been explored. In this study, a retrospective study was conducted in 86 cases of patients with glioblastoma after neurosurgery combined with chemoradiotherapy, and 36 cases with traumatic brain injury. Our results showed that miR-145 was significantly lower in glioblastoma tissues than that in normal brain tissue (P < 0.05). Furthermore, miR-145 was lower in patients with lower Karnofsky Performance Scale (KPS) scores than in patients with higher KPS scores ( P < 0.05). Cox Regression analysis showed that low miR-145 expression was associated with poor patient survival ( P < 0.05). These data suggested that patients with glioblastoma with lower miR-145 expression are prone to shorter overall survival. |
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| Keywords: | glioblastoma Karnofsky Performance Scale (KPS) miR-145 outcome |
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