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The prognostic and therapeutic values of long noncoding RNA PANDAR in colorectal cancer |
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| Authors: | Mahdi Rivandi Alireza Pasdar Leila Hamzezadeh Amir Tajbakhsh Sima Seifi Mehrdad Moetamani-Ahmadi Gordon A Ferns Amir Avan |
| Institution: | 1. Department of Modern Sciences 2. and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Division of Applied Medicine, Medical School, University of Aberdeen, Aberdeen, UK;4. Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;7. Division of Medical Education, Brighton & Sussex Medical School, Sussex, UK |
| Abstract: | Long noncoding RNAs (lncRNAs) consist of 200 nucleotide sequences that play essential roles in different processes, including cell proliferation, and differentiation. There is evidence showing that the dysregulation of lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) leads to the development and progression in several cancers including colorectal cancer, via p53-dependent manner. This suggests that these lncRNAs may be of value as prognostic indices and a therapeutic target, as a high expression of lncRNAs PANDAR is associated with poor prognosis. Furthermore, modulating lncRNAs PANDAR has been reported to induce apoptosis and inhibit the tumor growth through modulation of cell cycle and epithelial-mesenchymal transition (EMT) pathway. The aim of the current review was to provide an overview of the prognostic and therapeutic values of lncRNAs PANDAR in colorectal cancer |
| Keywords: | colorectal cancer long noncoding RNAs (lncRNAs) lncRNAs promoter of CDKN1A antisense DNA damage-activated RNA (PANDAR) prognostic biomarker therapeutic target |