Letters to the Editor

The following is the abstract of the article discussed in thesubsequent letter:

Venegas, José G., R. Scott Harris, and BrettA. Simon. A comprehensive equation for the pulmonarypressure-volume curve. J. Appl. Physiol. 84(1): 389-395, 1998.Quantification of pulmonary pressure-volume (P-V) curves isoften limited to calculation of specific compliance at a given pressureor the recoil pressure (P) at a given volume (V). These parameters can be substantially different depending on the arbitrary pressure orvolume used in the comparison and may lead to erroneous conclusions. Weevaluated a sigmoidal equation of the form, V = a + b[1 + e^(Pc)/d]¹, for its ability to characterize lung and respiratory system P-V curves obtained under a variety of conditions including normal andhypocapnic pneumoconstricted dog lungs (n = 9), oleicacid-induced acute respiratory distress syndrome (n = 2), andmechanically ventilated patients with acute respiratory distresssyndrome (n = 10). In this equation, a corresponds tothe V of a lower asymptote, b to the V difference between upperand lower asymptotes, c to the P at the true inflection pointof the curve, and d to a width parameter proportional to the Prange within which most of the V change occurs. The equation fittedequally well inflation and deflation limbs of P-V curves with a meangoodness-of-fit coefficient (R²) of 0.997 ± 0.02 (SD). When the data from all analyzed P-V curves were normalized by thebest-fit parameters and plotted as (V  a)/b vs.(P  c)/d, they collapsed into a single and tightrelationship (R² = 0.997). These resultsdemonstrate that this sigmoidal equation can fit with excellentprecision inflation and deflation P-V curves of normal lungs and oflungs with alveolar derecruitment and/or a region of gastrapping while yielding robust and physiologically useful parameters.