Growth signaling: TSC takes its place |
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| Authors: | Marygold Steven J Leevers Sally J |
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| Affiliation: | Growth Regulation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK. |
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| Abstract: | The protein products of the tumor suppressor genes tuberous sclerosis complex 1 and 2 form a protein complex, TSC1-TSC2, that inhibits growth. Several new studies suggest that TSC1-TSC2 does this by inhibiting TOR and S6 kinase, and that PI 3-kinase-Akt signaling relieves this inhibition. |
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