Leukemia-cell rejection due to T-region encoded antigens |
| |
Authors: | Giovanni Biasi Dino Collavo Paola Zanovello Luigi Chieco-Bianchi |
| |
Institution: | (1) Laboratory of Oncology, Institute of Pathological Anatomy, University of Padova, Padova, Italy |
| |
Abstract: | The role of H-2- and T-region products in determining allogeneic cell rejection was evaluated inH-2 congenic and recombinant mice by transplanting A1ATH and A6ATL leukemia cell lines induced in A.TH and A.TL strains, respectively, by Moloney murine leukemia virus. — InK- orD-region incompatible hosts transplant failure was observed, while inI +T-region incompatible hosts either rejection or prolonged survival was seen. In mice preimmunized with spleen cells fromI- and/orT-region incompatible donors, leukemia cells were rejected by mice immune only to T-region products, and accepted by mice immune only to I-region products. — Cell-mediated cytotoxicity studies confirmed in vivo results. Secondary CTLs specifically directed against I-region products did not lyse the A1ATH and A6ATL cells, and secondary CTLs from A.TH and A.TL mice sensitized against A6ATL and A1ATH cells respectively exerted a lytic action specific for T-region products, while no activity was observed against I determinants. — The data suggest that tumor-transplant rejection may also be governed by histocompatibility antigens encoded in theT region. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|