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Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests |
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| Authors: | Karl Egerer Dirk Roggenbuck Rico Hiemann Max-Georg Weyer Thomas Büttner Boris Radau Rosemarie Krause Barbara Lehmann Eugen Feist Gerd-Rüdiger Burmester |
| Affiliation: | 1.Department of Rheumatology and Clinical Immunology,Charité-Universit?tsmedizin Berlin,Berlin,Germany;2.GA Generic Assays GmbH,Dahlewitz/Berlin,Germany;3.University of Applied Science Lausitz,Senftenberg,Germany;4.Medizinisches Versorgungszentrum für Laboratoriumsmedizin, Mikrobiologie, Virologie und Infektionsepidemiologie,Hygiene und Umweltmedizin,Münster,Germany |
| Abstract: | IntroductionAnalysis of autoantibodies (AAB) by indirect immunofluorescence (IIF) is a basic tool for the serological diagnosis of systemic rheumatic disorders. Automation of autoantibody IIF reading including pattern recognition may improve intra- and inter-laboratory variability and meet the demand for cost-effective assessment of large numbers of samples. Comparing automated and visual interpretation, the usefulness for routine laboratory diagnostics was investigated. |
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