Synthesis and antifungal activity of a ferrocene-fluconazole analogue |
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| Authors: | Biot C François N Maciejewski L Brocard J Poulain D |
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| Affiliation: | Laboratoire de Catalyse de Lille, Groupe de Synthèse Organométallique, UPRESA CNRS 8010, Ecole Nationale Supérieure de Chimie de Lille, Villeneuve d'Ascq, France. ch_biot@club-internet.fr |
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| Abstract: | A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations. |
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