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Phenotypic error threshold; additivity and epistasis in RNA evolution
Authors:Nobuto?Takeuchi  author-information"  >  author-information__contact u-icon-before"  >  mailto:takeuchi_nobuto@yahoo.co.jp"   title="  takeuchi_nobuto@yahoo.co.jp"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,Petrus?H?Poorthuis,Paulien?Hogeweg
Affiliation:(1) Theoretical Biology/Bioinformatics Group, Utrecht University, Padualaan 8, 3584 Utrecht, CH, The Netherlands
Abstract:

Background  

The error threshold puts a limit on the amount of information maintainable in Darwinian evolution. The error threshold was first formulated in terms of genotypes. However, if a genotype-phenotype map involves redundancy ("mutational neutrality"), the error threshold should be formulated in terms of phenotypes since there is no unique fittest genotype. A previous study formulated the error threshold in terms of phenotypes, and their results showed that a rather low degree of mutational neutrality can increase the error threshold unlimitedly.
Keywords:
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