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Combined prime-boost vaccination against tick-borne encephalitis (TBE) using a recombinant vaccinia virus and a bacterial plasmid both expressing TBE virus non-structural NS1 protein |
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| Authors: | SE?Aleshin,AV?Timofeev,MV?Khoretonenko,LG?Zakharova,GV?Pashvykina,JR?Stephenson,AM?Shneider,AD?Altstein author-information" > author-information__contact u-icon-before" > mailto:altstein.ad@relcom.ru" title=" altstein.ad@relcom.ru" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Chumakov Institute of Poliomyelitis and Viral Encephalitis RAMS, Moscow Region, Russia;(2) Institute of Gene Biology RAS, Moscow, Russia;(3) London School of Hygiene and Tropical Medicine, London, UK;(4) Cure Lab Inc., Stoughton, MA, USA;(5) Engelhardt Institute of Molecular Biology RAS, Vavilov str. 32, 119991 Moscow, Russia |
| Abstract: | BackgroundHeterologous prime-boost immunization protocols using different gene expression systems have proven to be successful tools in protecting against various diseases in experimental animal models. The main reason for using this approach is to exploit the ability of expression cassettes to prime or boost the immune system in different ways during vaccination procedures. The purpose of the project was to study the ability of recombinant vaccinia virus (VV) and bacterial plasmid, both carrying the NS1 gene from tick-borne encephalitis (TBE) virus under the control of different promoters, to protect mice against lethal challenge using a heterologous prime-boost vaccination protocol. |
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