Oligomeric protein structure networks: insights into protein-protein interactions |
| |
Authors: | KV?Brinda Email author" target="_blank">Saraswathi?VishveshwaraEmail author |
| |
Institution: | (1) Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 560012 |
| |
Abstract: | Background Protein-protein association is essential for a variety of cellular processes and hence a large number of investigations are
being carried out to understand the principles of protein-protein interactions. In this study, oligomeric protein structures
are viewed from a network perspective to obtain new insights into protein association. Structure graphs of proteins have been
constructed from a non-redundant set of protein oligomer crystal structures by considering amino acid residues as nodes and
the edges are based on the strength of the non-covalent interactions between the residues. The analysis of such networks has
been carried out in terms of amino acid clusters and hubs (highly connected residues) with special emphasis to protein interfaces. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |