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Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England
Authors:Farhana Kauser   M Abid Hussain   Irshad Ahmed   Sriramula Srinivas   S Manjulata Devi   Ahmed A Majeed   K Rajender Rao   Aleem A Khan   Leonardo A Sechi  Niyaz Ahmed
Affiliation:(1) Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India;(2) ISOGEM Working Group on Genetics of Helicobacters [International Society for Genomic and Evolutionary Microbiology (ISOGEM)], Hyderabad, India;(3) Deccan Medical College and Allied Hospitals, Hyderabad, India;(4) Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Abstract:

Background  

Genomic diversity of H. pylori from many different human populations is largely unknown. We compared genomes of 65 H. pylori strains from Nottingham, England. Molecular analysis was carried out to identify rearrangements within and outside the cag-pathogenicity-island (cag PAI) and DNA sequence divergence in candidate genes. Phylogenetic analysis was carried out based on various high-resolution genotyping techniques.
Keywords:
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