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Comparative genomics of Helicobacter pylori isolates recovered from ulcer disease patients in England |
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| Authors: | Farhana Kauser M Abid Hussain Irshad Ahmed Sriramula Srinivas S Manjulata Devi Ahmed A Majeed K Rajender Rao Aleem A Khan Leonardo A Sechi and Niyaz Ahmed |
| Institution: | (1) Pathogen Evolution Group, Laboratory of Molecular and Cell Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India;(2) ISOGEM Working Group on Genetics of Helicobacters [International Society for Genomic and Evolutionary Microbiology (ISOGEM)], Hyderabad, India;(3) Deccan Medical College and Allied Hospitals, Hyderabad, India;(4) Department of Biomedical Sciences, University of Sassari, Sassari, Italy |
| Abstract: | BackgroundGenomic diversity of H. pylori from many different human populations is largely unknown. We compared genomes of 65 H. pylori strains from Nottingham, England. Molecular analysis was carried out to identify rearrangements within and outside the cag-pathogenicity-island (cag PAI) and DNA sequence divergence in candidate genes. Phylogenetic analysis was carried out based on various high-resolution genotyping techniques. |
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