Comparative analysis of mouse skeletal muscle fibre type composition and contractile responses to calcium channel blocker |
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| Authors: | Satu?M?ntt?ri Email author" target="_blank">Matti?J?rvilehtoEmail author |
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| Institution: | (1) Department of Biology, University of Oulu, Oulu, FIN-90014, Finland |
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| Abstract: | Background In this study, we examined the correlation between excitation-contraction coupling characteristics and skeletal muscle fibre
type by (1) localizing the distribution of dihydropyridine receptor (DHPR) protein and (2) comparing the effect of DHPR blocker
on muscles with different fibre type composition, in order to better understand the differences between contractile phenotypes
of fibres and to explain the contradictory reports to date on the interaction of dihydropyridines with skeletal muscle isoform
of DHPR. |
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