Dynamics of x-ray-induced reversion in heterogeneous S. cerevisiae populations. |
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Authors: | T Eklund |
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Institution: | 1. Institute of General Genetics, University of Oslo, Norway;2. Genetics Laboratory, Norsk Hydro''s Institute for Cancer Research, Oslo, Norway |
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Abstract: | The survival and frequency of adenine and homoserine revertants after X-irradiation have been studied in starved and growing populations of haploid S. cerevisiae (strain 5483/1b). A growing population is heterogeneous to cell killing, and a mathematical model can be used to determine possible correlation between sensitivity to killing and sensitivity to mutation induction. The results indicate correlation between sensitivity to ade2-1 reversion and sensitivity to cell killing, whereas no such correlation was found between sensitivity to hom3-10 reversion and sensitivity to killing. The difference in the dynamics of homoserine and adenine reversions was reduced by adding caffeine to the post-irradiation media. |
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