Role of 5-hydroxytryptamine in Moringa oleifera induced potentiation of pentobarbitone hypnosis in albino rats |
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| Authors: | Ray Kausik Hazra Rimi Debnath Pratip Kr Guha Debjani |
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| Institution: | Neurophysiology Laboratory, Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, India. |
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| Abstract: | The role of 5-hydroxytryptamine (5-HT) in pentobarbitone (PB) sleeping time, gross behaviour, electrical activity of the brain and serum 5-HT level was studied in Holtzman strain adult albino rats following treatment with M. oleifera (MO). MO (350mg/kg) caused inhibition of awareness, touch response, motor activity, righting reflex, and grip strength. It significantly increased the PB sleeping time, serum 5-HT level (P<0.001) and alpha-wave activity. These observations indicate that the aqueous extract of MO potentiated PB induced sleeping time and increased the alpha-wave activity through 5-HT. |
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