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Adrenal, kidney, and heart angiotensins in female murine ren-2 transfected hypertensive rats |
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| Authors: | P.deS Senanayake R.R Smeby A.S Martins A Moriguchi H Kumagai D Ganten K.B Brosnihan |
| Affiliation: | * Eye and Research Institutes, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA b 72 Hypertension CenterWake Forest University School of Medicine, Winston–Salem, North Carolina 27157, USA |
| Abstract: | We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1–7), and metabolites in the adrenal, kidney and heart of normotensive female Sprague–Dawley (SD) and transgenic hypertensive [TGR(mRen-2)27] rats carrying the murine Ren-2d renin gene. The monogenetic model of hypertensive rats had significant increases in adrenal Ang II; whereas in the kidney Ang II was unchanged, but Ang I and Ang-(1–7) were significantly lower. Cardiac Ang I, Ang II, and Ang-(2–10) were significantly reduced in transgenic rats, while Ang-(2–7) was increased. In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus. In female transgenic rats the increased adrenal Ang II and the sustained renal Ang II may contribute to the established phase of hypertension. |
| Keywords: | Blood pressure Transgenic hypertension Angiotensin peptides Renin gene |
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