YB-1与EGFR在子宫内膜异位症中表达的研究进展

YB-1,EGFR各自作为冷激蛋白和糖蛋白家族的成员表达于各种生理和环境的损伤之后,保护细胞的生存。近年来发现YB-1和EGFR在多种癌症及内异症中高表达,并且参与肿瘤和子宫内膜异位组织的发生,发展,分化及转移的各个方面。因而YB-1和EGFR的高表达能影响子宫内膜异位症的发生和发展;也说明YB-1和EGFR可以作为子宫内膜异位症患者一个潜在的诊断和治疗靶点。

Expression of YB-1 and EGFR in Endometriosis

The Y-box-bing Protein （YB-1） and epidermal growth factor receptor （EGFR）, each as a member of the family of cold shock proteins and glycoproteins, express after various physiological and environmental damage and protect the cell survival. In recent years, YB-1 and EGFR have been discovered to be over-expressed in various tumors and endometriosis, and to participate in the occurrence, development, differentiation and metastasis of tumors and endometriosis tissue. Thus, high expression of YB-1 and EGFR can influence the occurrence and development of endometriosis, also show that YB-1 and EGFR can be used ,as a potential diagnostic and therapeutic targets, for patients with endometriosis.