| 15-脂氧酶在子痫前期中的表达 |
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| 引用本文： | 王宇光,孟翠菊,王林娜,迟秀萍,郭蕾. 15-脂氧酶在子痫前期中的表达[J]. 现代生物医学进展, 2013, 0(2): 243-245 |
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| 作者姓名： | 王宇光 孟翠菊 王林娜 迟秀萍 郭蕾 |
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| 作者单位： | [1]哈尔滨医科大学附属第一医院妇产科,黑龙江哈尔滨150001 [2]哈尔滨医科大学药学院,黑龙江哈尔滨150086 |
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| 基金项目： | 黑龙江省教育厅科学技术研究（11541183） |
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| 摘 要： | 目的：探讨15-脂氧酶（15-LO）在子痫前期的病理生理过程中的作用。方法：采用蛋白印迹法检测15-LO的两种同工酶15-LO1和15-LO2在12名正常妊娠和16名子痫前期的孕妇胎盘和脐动脉组织中的表达。结果：在子痫前期的孕妇胎盘和脐动脉组织中,15-LO1蛋白质表达明显高于其在正常妊娠中的表达（P〈0.01）;而15-LO2在正常妊娠组不表达,其在子痫前期的孕妇胎盘和脐动脉组织中的表达显著高于其在正常妊娠中的表达（P〈0.01）。结论：15-LO在子痫前期的孕妇胎盘和脐动脉组织中高表达,可能与子痫前期的发生发展密切相关。
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| 关 键 词： | 15-脂氧酶 脐动脉 胎盘 子痫前期 |
The Role of 15-lipoxygenase in Preeclampsia |
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| WANG Lin-na,MENG Cui-jun,WANG Yu-guang,CHI Xiu-ping,GUO Lei. The Role of 15-lipoxygenase in Preeclampsia[J]. Progress in Modern Biomedicine, 2013, 0(2): 243-245 |
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| Authors: | WANG Lin-na MENG Cui-jun WANG Yu-guang CHI Xiu-ping GUO Lei |
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| Affiliation: | 1 Dept. of Obstetn＇cs and Gynecology, The first affiliated Hospital of Harbin Medical University, Harbin Heilongjiang, 150001,China, 2 The College of Pharrnacy, Harbin Medical University, Harbin, Heilongjiang, 150086, China) |
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| Abstract: | Objective： To compare the differential expression ot 15-hpoxygenase （,IS-LID） lsoenzymes, 15-LUI alia 15-LO2 m preeclampsia （PE）, and normal pregnancy and investigate the pathophysiological role of 15-LO in preeclampsia. Methods： We performed western blotting and isometric tension studies and t-test analysis on data from 6 women with normal pregnancy and 8 women with PE. Results： Expressions of 15-LO1 and 15-LO2 in placentas and umbilical cords in PE increased more than that in normal groups （P〈0.01）. 15-LO 1 expressed in placentas and umbilical cords in normal pregnancy, while 15-LO2 didn＇t express in normal groups. Conclusion： The high expression of 15-LO has close relationship with PE. |
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| Keywords: | 15-lipoxygenase Umbilical artery Placenta PE |
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