低血糖与2型糖尿病

糖尿病（DM）是一种慢性终身性疾病,目前已成为严重威胁人类健康的世界性公共卫生问题,2型糖尿病患者也逐渐增加。流行病学调查显示,目前全球大约有近2亿糖尿病患者,其中2型糖尿病占90%～95%。2型糖尿病发病机理是胰岛素分泌的相对或绝对不足伴有或不伴有胰岛素抵抗,持续的高血糖可严重抑制胰岛功能。严格的血糖控制能够延缓糖尿病慢性并发症的发生和发展,延长了患者的预期寿命。但是随着血糖控制达标,发生低血糖的危险性增加了,低血糖不仅严重阻碍了良好血糖控制,而且严重低血糖还是2型糖尿病致死、致残的重要原因。本文探讨2型糖尿病患者治疗中低血糖发生的原因、诱发因素以及可能的解决方案。

Hypoglycemia and Type 2 Diabetes Mellims

Diabetes mellitus is a chronic lifelong disease, which seriously threatening the human＇s health. Type 2 diabetes mellitus is becoming a worldwide public health problem and its incidence is increasing year by year. According to the Epidemiology investigation, there are about two hundred million diabetic patients and the Type 2 diabetes accounts for 90 % to 95 %. The pathogenesis of type 2 diabetes is defects in insulin secretion with or without insulin resistance, and the sustained hyperglycemia seriously inhibits the islet function. The tight glycemic control is an effective way of suppression chronic complications of diabetes and prolongation patient life expectancy. However, with the glycemic control improvement, the risk of hypoglycemia increases. Hypoglycemia not only severely hinders the glycemic control, but also causes disability or death with severe hypoglycemia. Therefore, Diabetes treatment is not only blood sugar control but also to reduce the incidence of hypoglycemia. This paper discusses causes of hypoglycemia and the causative factor in the treatment of type 2 diabetes patient as well as workable solutions.