肝纤维化动物模型造模方法的研究进展

肝纤维化是肝脏受到损伤后细胞外基质合成、降解与沉积不平衡的一种修复反应。对肝纤维化进行早期诊断、早期治疗,预防肝硬化的发生、发展,对肝病患者的生命质量具有重要的意义。而肝纤维化动物模型的建立,既可深入全面地研究肝纤维化发病机制,又可为临床筛选防治肝纤维化药物提供基础研究。通过对常用的肝纤维化动物模型造模方法的阐述,为肝纤维化的基础实验研究和临床治疗提供参考。

Study on Producing Methods of Animal Model of Hepatic Fibrosis

Hepatic fibrosis is a response to repair of unbalance between synthesis, degradation and deposition in the extracellular matrix after liver injury. Early diagnosis and treatment is of significance for preventing hepatic fibrosis and hepatic cirrhosis development as well as for improving life quality of hepatopath patients. The establishment of animal model of hepatic fibrosis can not only research pathogenesis of hepatic fibrosis deeply, but also provide basis for clinical medicine choice of preventing hepatic fibrosis, which will offer reference for basic research and clinical treatment of patients with hepatic fibrosis.