内皮前体细胞的动员与调节

胚胎发生时期,内皮前体细胞(endothelial progenitor cells,EPCs)参与了原始血管形成的最初过程(血管发生)。已有的证据显示,分化为内皮细胞(endothelial cells,Ecs)的前体也存在于成人中,正常情况下,EPCs停留在成人的骨髓,但是,可以通过细胞因子或血管生成因子信号被动员到循环血,迁移到生理或病理条件下的新血管形成位点,并原位分化成内皮细胞,快速和及时地修复损伤的血管。自源的EPCs原住动员或移植是治疗性血管再生的一个潜在、有效的方法,因此,探究EPCs从骨髓的动员和调节,对血管再生以及修复器官功能具有重要的意义。

Mobilization of Endothelial Progenitor Cells and Regulation in Post-natal Neovascularization

During embryogenesis,endothelial progenitor cells(EPCs)participate in the initial processes of primitive blood vessel formation(vasculogenesis).It has become evident that progenitors which differentiate into mature endothelial cells(Ecs)also exist in the adult.Endothelial progenitor cells(EPCs)normally reside in the adult bone marrow.However,they may be mobilized into circulation by cytokine or angiogenic growth factor signals,migrate to the neovascularization sites of physiology or pathology and differentiate into endothelial cells in situ,and then restore organ revascularization rapidly and timely.EPCs have also been considered as therapeutic agents to supply the potent origin of neovascularization under pathological conditions.Autologous endothelial progenitors mobilized in sire or transplanted,has become a major target of therapeutic revascularization approaches.For that reason,it is vital for revascularization and restoration of organ function to probe into the mobilization and regulation of endothelial progenitor cells from the bone marrow.