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Effects of chloramphenicol and thiamphenicol on sleep of the mouse] |
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| Authors: | K Kitahama J L Valatx |
| Abstract: | The oral administration of 0.25-2.0 g/kg of chloramphenicol at 9h selectively suppresses paradoxical sleep in mice for a duration of 2-4 hours. A dose of 1 g/kg given at 17h suppresses paradoxical sleep for 7 hours. Slow wave sleep decreased for 2 hours after administration. Thiamphenicol (1 g/kg) has no effect under the same conditions. |
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