Early antibodies to human serum albumin formed in germfree piglets |
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Authors: | J Rejnek L Prokešová J Trávníček |
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Institution: | (1) Department of Immunology, Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4 |
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Abstract: | Immunization of germfree piglets with HSA at the time of birth results in formation of antibodies of IgM, IgG and IgA classes
in spite of the fact that prior to immunization only IgG and IgA immunoglobulins are detectable in their sera. The possible
significance of this finding is discussed. Early IgG antibodies formed in these piglets differ from late and adult pig antibodies
by the presence of lower molecular weight constituents and their molecular heterogeneity corresponds to that of IgG of nonimmunized
newborn precolostral piglets suggesting that small amounts of immunoglobulins formed in piglets during the intrauterine life
are of antibody nature.
Dedicated to Prof. F. Patočka on the occasion of his 70th birthday
The work was supported by a WHO grant. |
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