| 紫草对心房颤动模型大鼠的影响 |
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| 引用本文： | 季佳文,周谦,王玥,沈建平.紫草对心房颤动模型大鼠的影响[J].中国野生植物资源,2019(2):25-28. |
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| 作者姓名： | 季佳文 周谦 王玥 沈建平 |
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| 作者单位： | 南京中医药大学;南京中医药大学第三临床医学院;南京中医药大学附属中西医结合医院;江苏省中医药研究院 |
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| 摘 要： | 目的:探讨紫草对房颤模型大鼠的心房颤动的发生及发展的作用及相关机制。方法:大鼠通过尾静脉连续给乙酰胆碱-氯化钙(Ach-CaCl_2)造模。第6天开始,紫草组予紫草汤药灌胃,胺碘酮组予胺碘酮溶液灌胃,空白组和模型组予生理盐水灌胃。于第14天进行心电图检查并记录房颤的诱发时间及持续时间,之后,超声心电图检查以记录左房面积(LA area)、射血分数(EF%)、左室舒张末径(LVDD)、左室收缩末径(LVDS),以评估紫草对模型大鼠的心脏重构和功能的影响。结果:1.紫草降低心房颤动大鼠的心房颤动诱发率并缩短了心房颤动的持续时间;2.紫草使心房颤动大鼠的心房重构改善,表现为左房面积和左室内径的减小,但对EF值无明显影响。
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| 关 键 词： | 心房颤动 大鼠 紫草 中草药 超声心电图 |
Radix Arnebiae Improve Atrial Fibrillation in Rats |
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| Ji Jiawen,Zhou Qian,Wang Yue,Shen Jianping.Radix Arnebiae Improve Atrial Fibrillation in Rats[J].Chinese Wild Plant Resources,2019(2):25-28. |
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| Authors: | Ji Jiawen Zhou Qian Wang Yue Shen Jianping |
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| Institution: | (Nanjing University of Chinese Medicine,Nanjing 210023,China;The Third Clinical School of Nanjing University of Chinese Medicine,Nanjing 210028,China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China) |
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| Abstract: | Ji Jiawen;Zhou Qian;Wang Yue;Shen Jianping(Nanjing University of Chinese Medicine,Nanjing 210023,China;The Third Clinical School of Nanjing University of Chinese Medicine,Nanjing 210028,China;Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China) |
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| Keywords: | Atrial fibrillation rats Radix Arnebiae echocardiogram |
| 本文献已被 CNKI 维普 等数据库收录！ |
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