Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter |
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| Authors: | Nahida Haddam Sekkal Samira Xavier Dumont Abdesselem Taleb Vincent Haufroid Dominique Lison |
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| Institution: | 1. Laboratory of Medical Toxicology (ToxicoMed), Faculty of Medicine, University Abou Bekr Belkaid, Tlemcen, Algeria;2. Unit of Industrial Toxicology and Occupational Medicine, Catholic University of Louvain, Belgium |
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| Abstract: | Serum Clara cell protein (CC16) and surfactant-associated protein D (SP-D) were measured in 161 workers exposed to sulphur dioxide (SO2) in a non-ferrous smelter. Seventy workers from a blanket manufacture served as referents. Exposure to SO2 and tobacco smoking were associated with a decrease of CC16 and an increase of SP-D in serum. Tobacco smoking and exposure SO2 interacted synergistically to decrease serum CC16 but not to increase serum SP-D. While further illustrating the potential of serum CC16 and SP-D, our study confirms that SO2 can cause airways damage at exposure levels below current occupational exposure limits. |
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| Keywords: | Clara cell protein surfactant-associated protein D sulphur dioxide exposure lung epithelium pneumoprotein |
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