Changes in fatty acid composition associated with differentiation of Trypanosoma cruzi |
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| Authors: | Manuel G. Esteves Magaly Gonzales-Perdomo Celuta S. Alviano Jayme Angluster Samuel Goldenberg |
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| Affiliation: | Instituto de Microbiologia, UFRJ, Cidade Universitaria, Rio de Janeiro, Brasil. |
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| Abstract: | The fatty acid composition during the transformation of Trypanosoma cruzi epimastigotes into metacyclic trypomastigotes (metacyclogenesis) was analysed by gas-liquid chromatography and mass spectrometry. Significant qualitative and quantitative changes in the fatty acid composition occurred during incubation of epimastigotes derived from LIT medium in the triatomine artificial urine (TAU). Metacyclogenesis was also followed by alterations in the fatty acid pattern but these were considerably less pronounced when compared to the pattern obtained for TAU-incubated epimastigotes. These results suggest that changes in the lipid composition precede the morphological transformation of epimastigotes into metacyclic trypomastigotes. |
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| Keywords: | Trypanosoma cruzi Fatty acid Lipid Cell differentiation |
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