| Is rat skeletal muscle hexokinase an allosteric enzyme? |
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| 收稿时间： | 1987-02-20 |
Is rat skeletal muscle hexokinase an allosteric enzyme? |
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| M B Bass,H J Fromm. Is rat skeletal muscle hexokinase an allosteric enzyme?[J]. Archives of biochemistry and biophysics, 1987, 256(2): 708-711. DOI: 10.1016/0003-9861(87)90629-1 |
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| Authors: | M B Bass H J Fromm |
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| Affiliation: | 1. Madras Diabetes Research Foundation & Dr. Mohan''s Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control, ICMR Centre for Advanced Research on Diabetes, Gopalapuram, Chennai, India;2. Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom;3. Department of Obstetrics and Gynecology, Seethapathy Clinic and Hospital, Chennai, Tamil Nadu, India;1. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA |
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| Abstract: | A recent report by M. Gregoriou, I. P. Trayer, and A. Cornish-Bowden (1986, Eur. J. Biochem. 161, 171-176) showed that the mechanism for rat skeletal muscle hexokinase contains two allosteric sites: one for ATP and one for glucose 6-phosphate. In this report, we show that the allosteric mechanism is at variance with a large amount of kinetic data for the skeletal muscle hexokinase reaction in the literature. In addition, the allosteric mechanism conflicts with isotope exchange at chemical equilibrium data reported by M. Gregoriou, I. P. Trayer, and A. Cornish-Bowden (1983, Eur. J. Biochem. 134, 283-288). |
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