Comparative study of the effectiveness of HBcAg presentation to the immune system using attenuated Salmonella strains, serovars S.enteritidis and S.typhimurium |
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Authors: | Karpenko L I Veremeĭko T A Ignat'ev G M Poryvaeva V A Baĭborodin S I Boĭchenko M N Il'ichev A A Vorob'ev A A |
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Affiliation: | State Research Center of Virology and Biotechnology Vector-Research Institute of Bioengineering, Closed Joint-Stock Company Vector-Best, Koltsovo, Novosibirsk Region, Russia. |
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Abstract: | In this work the results of obtaining HBcAg-producing attenuated Salmonella strains, serovars S. enteritidis and S. typhimurium, and their comparative study is presented. As revealed in this study, attenuated S. enteritidis strain E-23 and S. typhimurium strain T-10, producing HBcAg, induce cell-mediated and humoral immune response to HBcAg after injected into anovals. After injection S. typhimurium strain T-10 induces a much higher titer of specific antibodies than S. enteritidis strain E-23. The level of specific antibodies induced by recombinant HBcAg seems to correlate with the capacity of salmonellae for survival inside macroorganisms. |
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