Kalirin Signaling: Implications for Synaptic Pathology |
| |
Authors: | Peter Penzes Christine Remmers |
| |
Institution: | (1) Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA;(2) Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Avenue, Chicago, IL 60611, USA |
| |
Abstract: | Spine morphogenesis and plasticity are intimately linked to cognition, and there is strong evidence that aberrant regulation
of spine plasticity is associated with physiological, behavioral, and pathological conditions. The neuronal guanine nucleotide
exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines.
Here, we review recent studies that have genetically and functionally linked kalirin signaling to a number of human disorders.
Kalirin signaling may thus represent a disease mechanism and provide a novel therapeutic target. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|