Proteomic identification of activin receptor-like kinase-1 as a differentially expressed protein during hyaloid vascular system regression |
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Authors: | Albè Elena Escalona Elizabeth Rajagopal Rama Javier Joel A Chang Jin-Hong Azar Dimitri T |
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Institution: | Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. |
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Abstract: | The hyaloid vascular system (HVS) is a transient network of capillaries that nourishes the embryonic lens and the primary vitreous of the developing eye. We used proteomic analysis and immunohistochemical staining to identify activin receptor-like kinase-1 (ALK1), a type I receptor for transforming growth factor-beta1, during the HVS regression phase. In addition, we overexpressed ALK1 in corneas implanted with bFGF (basic fibroblast growth factor) pellets and observed that ALK1 overexpression resulted in inhibition of bFGF-induced corneal neovascularization in vivo. Our data suggest that ALK1 may play a role in HVS regression during ocular development. |
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Keywords: | Activin receptor-like kinase-1 Hyaloid vascular system regression |
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