The role of fractions from Paracoccidioides brasiliensis in the genesis of inflammatory response |
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| Authors: | Lucia Maria Carareto Alves Floréncio Figueiredo Sebastião Lázaro Brandão Filho Izaira Tincani Célio L Silva |
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| Institution: | (1) University of Alberta Microfungus Collection and Herbarium, T6G 2H7 Edmonton, Alberta, Canada;(2) CAB International Mycological Institute, IUMS International Commission on the Taxonomy of Fungi, Ferry Lane, TW9 3AF Kew, Surrey, UK |
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| Abstract: | The influx of inflammatory cells towards the peritoneal cavity in rats inoculated intraperitoneally with subcellular preparations of the fungus Paracoccidioides brasiliensis was studied. In addition to the dead fungus, also fractions F1 of the cell wall, which mainly consisted of polysaccharides and the lipid extract, induced intense cell migration 4 hr after inoculation, with a greatly increased number of polymorphonuclear leucocytes (PMN). Study of the kinetics of cell influx showed that both fraction F1 and the lipid extract initially induced intense PMN migration between the 4th and 24th hr after inoculation of these agents, followed by migration of mononuclear cells (MN) around the 48th hr. We also observed that migration of these cells increased gradually after inoculation of growing doses of fraction F1. The present data suggest that polysaccharides and lipids isolated from P. brasiliensis may participate in the initial phase of the inflammatory response in paracoccidioidomycosis. |
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| Keywords: | Paracoccidioides brasiliensis paracoccidioidomycosis acute inflammation lipids cell wall polysaccharide |
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