| 肝部分切除后肝再生增强因子信使核糖核酸（mRNA）表达增强 |
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| 引用本文： | 杨晓明,谢玲.肝部分切除后肝再生增强因子信使核糖核酸（mRNA）表达增强[J].生理学报,1997,49(5):599-601. |
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| 作者姓名： | 杨晓明 谢玲 |
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| 作者单位： | 军事医学科学院放射医学研究所!北京，100850，军事医学科学院放射医学研究所!北京，100850，军事医学科学院放射医学研究所!北京，100850，军事医学科学院放射医学研究所!北京，100850 |
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| 基金项目： | 国家863计划基金!863-102-08-5 |
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| 摘 要： | 肝再生增强因子（ＡＬＲ）是一种新的肝增殖刺激因子。本研究选择７０％肝部分切除（ＰＨ）大鼠为模型，观察了ＰＨ后残存肝组织胞浆液促肝细胞增殖活性与ＡＬＲ特异ｍＲＮＡ表达动态变化的关系。发现正常肝组织几无ＡＬＲ ｍＲＮＡ表达，其肝胞质液也无促肝细胞增殖活性；７０％ＰＨ后１２ｈ肝组织ＡＬＲ ｍＲＮＡ表达明显增加，并于术后２４ｈ达高峰，肝胞质液活性也于术后２４ｈ内达高峰，这种ｍＲＮＡ表达－效应的时间关系提示
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| 关 键 词： | 肝部分切除 肝再生增强因子 mRNA |
INCREASE IN THE LEVEL OF AUGMENTER OF LIVER REGENERATI0N mRNA IN THE RAT REGENERATING LIVER AFTER PARTIAL HEPATECTOMY |
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| YANG XIAO-MING, XIE LING, WU ZU-ZE.INCREASE IN THE LEVEL OF AUGMENTER OF LIVER REGENERATI0N mRNA IN THE RAT REGENERATING LIVER AFTER PARTIAL HEPATECTOMY[J].Acta Physiologica Sinica,1997,49(5):599-601. |
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| Authors: | YANG XIAO-MING XIE LING WU ZU-ZE |
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| Abstract: | Augmenter of liver regeneration (ALR) is a novel hepatic stimulator. After 7O% of the rat liver was removed, ALR-like activity in the remnant liver began to increase within 24 h. In parallel with the activity, the ALR mRNA level in the remnant liver increased 12 h after the 0peration and reached a maximum in 24 h. These findings indicate that the liver itself produees ALR, which may be a hepatotropic factor acting as a trigger for liver regeneration. |
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| Keywords: | augmenter of liver regeneration mRNA liver regeneration partial hepatectomy |
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