Amphetamine stimulation of glutaminase is blocked by neuroleptics |
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| Authors: | A D Sherman J Mott |
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| Affiliation: | Neurochemical Research Laboratory Department of Psychiatry University of Iowa Iowa City, Iowa 52242, USA |
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| Abstract: | The ability of several classes of neuroleptics to inhibit the activity of phosphate-activated glutaminase was studied in several brain regions. These agents decreased glutaminase activity only in the amygdala. Amphetamine elevated glutaminase activity in this region. This stimulation was not blocked by (-) butaclamol, but was blocked by (+) butaclamol, haloperidol, chlorpromazine or clozapine. |
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