Neutron RBE for primate spinal cord treated with clinical regimens. |
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| Authors: | T E Schultheiss L C Stephens K K Ang J H Jardine L J Peters |
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| Affiliation: | Division of Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030. |
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| Abstract: | The RBEs of high-energy neutrons given in 9 or 12 fractions for cervical spinal cord injury in rhesus monkeys was determined using photons at 2.2 Gy per fraction as the reference radiation. Because the dose-response functions were not parallel, the RBE was not constant but rather increased with dose or, equivalently, with the probability of myelopathy. This required the development of a novel method of determining the RBE versus level of response. The RBE is presented as a function of probability of myelopathy from 0.1 to 99%. At a 50% incidence of myelopathy, the RBE (+/- 1 SE) was 5.22 +/- 0.15. A difference in the histopathology of lesions induced by photon and neutron treatments was observed. |
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