In vitro autologous blast cell sensitization as immunotherapy in acute non-lymphocytic leukemia |
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Authors: | J. W. Thomas J. F. Denegri L. R. Grossman N. Morgan K. Munn |
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Affiliation: | (1) Departments of Pathology and Medicine, Vancouver General Hospital and the University of British Columbia, 855 West 12th Avenue, V5Z 1M9 Vancouver, B.C., Canada |
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Abstract: | Summary Remission mononuclear cells incubated in vitro for 96 h with autologous stored blast cells were reinfused IV on two occasions as adjuvant maintenance therapy. The procedures were well tolerated, but in vitro response to the blast cells was negligible.The present mean duration of complete remission (15.7 months) appears to be similar to that of 28 patients (12.4 months) treated at the same time with chemotherapy alone by the same physicians. |
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